The Department of Defense Neurofibromatosis (NF) Research Program recently awarded Drs. Joshua Breunig (Cedars Sinai), David Gutmann (Washington University), and Yuan Pan (MD Anderson Cancer Center) a three-year grant to study NF1-associated brain tumors. The team will leverage a state-of-the-art genetic technology called Mosaic Analysis with Dual Recombinases (MDAR) to model brain tumors in NF1 […]
Lara Marquez Y Marco, an undergraduate researcher in the Washington University NF Center, was recently awarded a summer Pediatric Oncology Student Training (POST) Program grant from Alex’s Lemonade Stand Foundation. For her summer project, Lara will work with senior postdoctoral fellow, Dr. Jit Chatterjee, in the laboratory of Dr. David Gutmann, to explore the relationship […]
Corina Anastasaki and Yuan Pan (MD Anderson) were recently invited to present their work for the cancer neuroscience session at the Pediatrics Society for Neuro-Oncology meeting in Washington D.C. (June 2023). Cancer neuroscience is a new and emerging field in cancer research that explores the notion that neurons, the nerves of our body, are not […]
The laboratory of Dr. Angela Hirbe, along with collaborators in the Largaespada and Wood labs at the University of Minnesota, the Pratilas lab at Johns Hopkins University, and the Gosline lab have just published a novel three-dimensional MPNST culture system to test novel therapeutic combinations. They hope this system will allow for high throughput testing of […]
Drs. Yuan Pan (Assistant Professor, UT MD Anderson Cancer Center) and Nicole Brossier (Assistant Professor, Washington University) were recently awarded a three-year grant from the Department of Defense NF Research Program to study the interaction between Nf1 mutation and maternal diet. Together, Drs. Pan and Brossier will study how genetic and environmental factors both individually […]
Anna Wilson has finished her two-year tenure as a postbaccalaureate researcher in the Gutmann laboratory and will move to Boston to start medical school at Harvard this fall. Anna joined the lab as an undergraduate research trainee in the fall of 2019, eventually completing her senior honors thesis before graduating Summa Cum Laude from Washington […]
We are so excited to welcome Michelle to the Gutmann Laboratory. In her role, she will serve as one of the Gutmann Lab managers. Her previous research experience at the University of Missouri – Columbia was in cardiovascular physiology focused on calcium homeostasis in the heart. Her favorite part of working in the lab was […]
Dr. Dana Borcherding, a senior scientist in the laboratory of Dr. Angela Hirbe, recently found that the combination of two drugs targeting different growth control pathways in MPNST cells dramatically decreased tumor growth in mice. In their studies, they combined a TYK2 inhibitor with a MEK inhibitor to achieve this dramatic effect with minimal toxicity. […]
Dr. Yuan Pan, Assistant Professor at the University of Texas MD Anderson Cancer Center, was recently awarded a three-year grant from the Gilbert Family Foundation Vision Restoration Initiative to study how NF1 mutations in brain cells called oligodendroglial cells change their interactions with the optic nerve. In this grant, Dr. Pan’s team will work with Dr. Corina Anastasaki, Research […]
Dr. Susan Maloney, Research Assistant Professor in Psychiatry, was recently awarded a one-year grant from the Washington University Intellectual and Developmental Disabilities Research Center (IDDRC) to study social behavior in mice with different Nf1 gene mutations. In this grant proposal, Dr. Maloney will collaborate with Dr. Corina Anastasaki, Research Assistant Professor in Neurology, to identify the autism-related behaviors in Nf1-mutant […]
The Children’s Tumor Foundation (CTF) has announced a groundbreaking 3-year study, which it will fund for nearly $2 million, to determine if a DNA-based blood test can offer better understanding and ultimately earlier diagnosis of cancer predisposition in neurofibromatosis type 1 (NF1) patients. Approximately 7-15% percent of NF1 patients may develop malignant peripheral nerve sheath […]