Schwannomatosis (SWN) is an umbrella term encompassing multiple forms of SWN in which affected individuals develop benign tumors associated with nerves (schwannomas). SWN is the least common form of NF, with no clear genetic inheritance pattern. Subtypes of SWN include:
- NF2-related schwannomatosis
- SMARCB1-related schwannomatosis
- LZTR1-related schwannomatosis
- 22q-related schwannomatosis
- Schwannomatosis NOS
- Schwannomatosis NEC
Some forms of SWN affect 1 in 20,000 individuals (NF2-related SWN), whereas other subtypes affect only 1 in 70,000. There is currently no cure for SWN; however, surgical intervention to remove schwannomas is possible. Research into the causes of these tumors has resulted in new medical treatments offered as part of clinical trials.