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The Washington University NF Center is focused on accelerating the pace of scientific discovery and its application to the care of individuals with NF.

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NF Center Researchers Discover a New Target for Potential MPNST Treatment

In an effort to discover new genetic mutations in malignant peripheral nerve sheath tumors (MPNSTs), deadly sarcomas , Dr. Angela Hirbe and her colleagues at the Washington University NF Center employed a sequencing platform currently available to most cancer patients. This screening platform was designed to detect mutations in genes that can be targeted by novel drug compounds.

Dr. Matthew Stroh Joins the Gutmann Laboratory

We would like to welcome Dr. Matthew Stroh to the Gutmann Laboratory. After graduating with honors with a PhD in Neuroscience from the University of Kansas Medical Center (KUMC), Dr. Stroh joined the laboratory as postdoctoral research fellow. His work is primarily focused on understanding how growth is controlled in brain cells relative to other tissues, and he is particularly interested in determining how cells differentially use a limited number of critical signaling molecules to create a high degree of functional diversity.

Female Hormones Increase Risk of Vision Loss in NF1

Recent NF Center research has revealed that female sex hormones are the underlying reason why girls with NF1 who have an optic pathway glioma are much more likely to lose their vision than boys. Understanding why boys and girls with mutations in the same gene have different outcomes presents unprecedented opportunities to fix the problem.

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