Neurofibromatosis type 1 (NF1) is one of the most common cancer predisposition syndromes, where children are prone to develop low-grade brain tumors. In order to better define the MRI features and natural history of non-optic pathway tumors (non-OPTs) in children with NF1, Dr. Jasia Mahdi conducted a retrospective cross-sectional analysis of 64 children with NF1 harboring 100 non-OPTs. Their findings showed that the majority of non-OPTs grew over time and caused medical problems. In addition, she also identified a small subset of children with a particularly aggressive form of brain tumor, which tended to arise in younger children. The researchers hope that these findings will improve the recognition and management of children with NF1.