NF Center Articles

Sun T, Gianino SM, Jackson E, Piwnica-Worms D, Gutmann DH, Rubin JB: CXCL12 alone is insufficient for gliomagenesis in Nf1 mutant mice. J. Neuroimmunol. (in press).

Warrington NM, Gianino SM, Jackson E, Goldhoff P, Garbow JR, Piwnica-Worms D, Gutmann DH, Rubin JB: Cyclic AMP suppression is sufficient to induce gliomagenesis in a mouse model of neurofibromatosis-1. Cancer Res (in press).

Kim K-Y, Ju WK, Hegedus B, Gutmann DH, Ellisman ME: Ultrastructural Characterization of the Optic Pathway in a Mouse Model of Neurofibromatosis-1 Optic Glioma. Neuroscience (in press).

Scott A, Powner MB, Gandhi P, Clarkin C, Gutmann DH, Johnson R, Ferrara N, Fruttiger M: Astrocyte-derived vascular endothelial growth factor stabilizes vessels in the developing retinal vasculature. PLOS One (in press).

Payton JE, Schmidt J, Yu J, Lusis EA, Watson MA, Gutmann DH: Genome-wide polymorphism analysis demonstrates a monoclonal origin of pilocytic astrocytoma. Neuropathology and Applied Neurobiology (in press).

Doward IG, Luo J, Perry A, Gutmann DH, Mansur DB, Rubin JB, Leonard JR: Post-operative imaging surveillance in pediatric pilocytic astrocytomas. J. Neurosurg. Ped. (in press).

Brown JA, Gianino SM, Gutmann DH: Defective cyclic AMP generation underlies the sensitivity of central nervous system neurons to neurofibromatosis-1 heterozygosity. J Neurosci 30:5579-89, 2010.

Banerjee S, Byrd JN, Gianino SM, Harpstrite SE, Rodriguez FJ, Tuskan RG, Reilly KM, Piwnica-Worms DR, Gutmann DH: Neurofibromin controls cell growth by regulating STAT3 activity in vitro and in vivo. Cancer Res 70:1356-66, 2010.

Claus EB, Abdel-Wahab M, Burger PC, Engelhard HH, Ellison DW, Gaiano N, Gutmann DH, Heck D, Holland EC, Jallo GI, Kruchko C, Kun LE, Maria BL, Rumbolt Z, Spinella GM, Stophel L, Wechsler-Reya R, Wrensch M, Gilbertson RJ: Defining Future Directions in Spinal Cord Tumor Research: National Institutes of Health Workshop Report. J Neurosurg Spine 12:117-121, 2010.

Rauen KA, Schoyer L, McCormick F, Lin AE, Allanson JE, Stevenson DA, Gripp KW, Neri G, Carey JC, Legius E, Tartaglia M, Schubbert S, Robert AE, Gelb BD, Shannon K, Gutmann DH, McMahon M, Guerra MC, Fagin JA, Yu B, Aoki Y, Neel BG, Balmain A, Drake DR, Nolan GP, Zenker M, Bollag G, Sebolt-Leopold J, Gibbs JB, Silva AJ, Patton EE, Viskochil DH, Kieran MW, Korf BR, Hagerman RJ, Packer RJ, Melese T: Proceedings from Genetic Syndromes of the Ras/MAPK Pathway: From Bedside to Bench and Back 2009. Am J Med Genet A 152A:4-24, 2010.

Schiffman JD, Hodgson JG, Vandenberg SR, Flaherty P, Polley M-YC, Yu M, Fisher PG, Rowitch DH, Ford JM, Berger MS, Ji H, Gutmann DH, James CD: Combined oncogenic BRAF mutation and CDKN2A inactivation is characteristic of a subset of pediatric malignant astrocytomas. Cancer Res 70:512-519, 2010.

Bhola P, Banerjee S, Mukherjee J, Balasubramanium A, Arun V, Karim Z, Burrell K, Croul S, Gutmann DH, Guha A: Preclinical in vivo evaluation of rapamycin in human malignant peripheral nerve sheath tumor explant xenografts. Int J Cancer 126:563-71, 2010.

Darken R, Bogitch R, Leonard J, Perry A, McKinstry RC, Gutmann DH, Rubin JB: Brainstem glioma presenting as pruritus in children with neurofibromatosis-1. J Ped Hem-Onc. 31:972-976, 2009.

Yu J, Deshmukh H, Gutmann RJ, Emnett RJ, Rodriguez FJ, Watson MA, Nagarajan R, Gutmann DH: Alterations of BRAF and HIPK2 loci predominate in sporadic pilocytic astrocytoma. Neurology 73:1526-31, 2009. [chosen for editorial]

Mawrin C, Wolke C, Haase D, Kruger S, Firsching R, Keilhoff G, Paulus W, Gutmann DH, Lal A, Lendeckel U: Reduced activity of CD13/aminopeptidase N (APN) in aggressive meningiomas is associated with increased levels of SPARC. Brain Pathol. Epub Feb 18, 2009.

Dickinson PJ, Surace EI, Cambell M, Higgins RJ, Leutenegger CM, Bollen AW, LeCouteur RA, Gutmann DH: Expression of the tumor suppressor genes NF2, 4.1B, and TSLC1 in canine meningiomas. Vet Pathol. 46:884-892, 2009.

Nunley KS, Gao F, Albers AC, Bayliss SJ, Gutmann DH: Predictive value of café-au-lait macules at initial consultation in the diagnosis of neurofibromatosis type 1. Arch Dermat. 145:883-887, 2009.

Yeh T-H, Lee DY, Gianino SM, Gutmann DH: Microarray analyses reveal regional astrocyte heterogeneity with implications for neurofibromatosis type 1 (NF1)-regulated glial proliferation. GLIA 57:1239-49, 2009.

Hegedus B, Hughes WF, Garbow JR, Gianino S, Banerjee D, Kim K, Ellisman MH, Brantley MA, Gutmann DH: Optic nerve dysfunction in a mouse model of neurofibromatosis-1 optic glioma. J Neuropathol Exp Neurol. 68:542-551, 2009. [cover feature]

Houshmandi SS, Emnett RJ, Giovannini M, Gutmann DH: The neurofibromatosis-2 protein, merlin, regulates glial cell growth in an ErbB2- and Src-dependent manner. Mol Cell Biol. 29:1472-86, 2009.

Tibbetts KM, Emnett RJ, Gao F, Perry A, Gutmann DH, Leonard J: Histopathologic predictors of pilocytic astrocytoma event-free survival. Acta Neuropathologica 117:657-665, 2009.

Filion C, Motoi T, Olshen A, Lae M, Emnett RJ, Gutmann DH, Perry A, Ladanyi M. Labelle Y: The EWSR1/NR4A3 fusion protein of extraskeletal myxoid chondrosarcoma activates the PPARG nuclear receptor: use of tumor expression profiles to guide the search for candidate transcriptional target genes. J Pathol 217:83-93, 2009.

Jost SC, Ackerman JW, Garbow JR, Manwaring LP, Gutmann DH, McKinstry RC: Diffusion-weighted and dynamic contrast-enhanced imaging as markers of clinical behavior in children with optic pathway glioma. Pediatric Radiology 38:1293-1299, 2008.

Daginakatte GC, Gianino SM, Zhao NW, Parsadanian AS, Gutmann DH: Increased JNK signaling in Neurofibromatosis-1 (Nf1) heterozygous microglia drives microglia activation and promotes optic glioma proliferation. Cancer Res. 68:10358-10366, 2008.

Rodriguez FJ, Giannini C, Asmann YW, Sharma MK, Perry A, Tibbetts KM, Jenkins RB, Scheithauer BW, Anant S, Jenkins S, Eberhart EG, Sarkaria JN, Gutmann DH: Gene expression profiling of NF1-associated and sporadic pilocytic astrocytomas identifies ALDH1L1 as an underexpressed candidate biomarker in aggressive astrocytoma subtypes. J Neuropath Exp Neurol. 67:1194-1204, 2008. [cover feature]

Cui Y, Costa RM, Murphy GG, Elgersma Y, Zhu Y, Gutmann DH, Parada LF, Mody I, Silva AJ: Neurofibromin regulation of Ras/ERK signaling modulates GABA release and learning. Cell 135:549-560, 2008.

Striedinger K, McDermott MW, VandenBerg SR, Gutmann DH, Lal A: The neurofibromatosis 2 tumor suppressor gene product, merlin, regulates human meningioma cell growth through YAP. Neoplasia 10:1204-1214, 2008.

For more articles and abstracts, take this off-site link to the National Library of Medicine Pub Med page for Dr. David H. Gutmann